Cover of “Essential Biochemistry for Medical Students with Problem-Solving Exercises”

Essential Biochemistry for Medical Students with Problem-Solving Exercises

учебник

ed. by Glukhov А.I., Gubareva A.E.

  • ГЭОТАР-Медиа
  • 2024
  • 584 pages

Medical subjects

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This textbook is based on the Biochemistry lecture course of the Biological Chemistry Department, I.M. Sechenov First Moscow State Medical University. The textbook focuses on the modern basic principles of Biochemistry. This fi rst edition comprehensively covers the molecular basics of the human organism functioning in normal conditions and during adaptation to the changing environment. The book also provides modern insight into the molecular mechanisms of the most common human pathological conditions. Each topic includes the appropriate tests and situational problems, allowing to study the material more interactively and train students in clinical problem solving and diagnostic reasoning.

The book "Essential Biochemistry for Medical Students with Problem-Solving Exercises" is intended for medical and pharmacy students studying in English, Biochemistry postgraduate students, and teachers.

  1. 01Authours
  2. 02List of abbreviations
  3. 03Chapter 1. The structure, properties and functions of proteins
    1. 1.1. Biological Functions of Proteins
    2. 1.2. Structures, Properties and Classification of Amino Acids
    3. 1.3. The Levels of Protein Structures: Primary, Secondary, Tertiary
    4. 1.4. Quaternary Structure of Proteins. Hemoglobin
    5. 1.5. Physical Chemical Properties of Proteins
    6. 1.6. Diseases Associated with Structure and Function Proteins Disorders
  4. 04Chapter 2. Enzymes
    1. 2.1. Enzymes as Catalysts. Active Site of the Enzyme
    2. 2.2. Vitamins. Cofactors and Coenzymes
    3. 2.3. Enzymes Classification and Nomenclature
    4. 2.4. Regulation of Enzymes and Metabolic Pathways. Inhibition of Enzymes. Drugs as Inhibitors of Enzymes
    5. 2.5. Clinical Applications of Enzymes. Plasma Proteins and Enzymes in Diagnosis of Diseases
  5. 05Chapter 3. Gene expression and protein synthesis
    1. 3.1. Nucleic Acid Structure
    2. 3.2. DNA Replication
    3. 3.3. DNA Damage & Repair
    4. 3.4. Transcription: RNA Synthesis
    5. 3.5. Genetic Code Properties
    6. 3.6. Translation: Protein Synthesis
    7. 3.7. Protein Posttranslational Modifications
    8. 3.8. DNA, RNA and Protein Synthesis Inhibitors
    9. 3.9. The Regulation of Gene Expression
    10. 3.10. The Effects of Mutations
    11. 3.11. Recombinant DNA Technology
  6. 06Chapter 4. Structure and functions of biological membranes. Cell signaling pathways
    1. 4.1. General Description of Membranes: Composition and Structure
    2. 4.2. Transmembrane Transport
    3. 4.3. Transmembrane Signal Transduction
    4. 4.4. Signal Transduction by Intracellular Receptors
  7. 07Chapter 5. Catabolism and cellular bioenergetics
    1. 5.1. Energy Producing and Energy Utilizing Reactions. The ATP-ADP Cycle. Specific and Common Catabolic Pathways
    2. 5.2. A Common Pathway for the Final Oxidation of Metabolic Fuels
    3. 5.3. Tricarboxylic ACID cycle (TCA cycle)
    4. 5.4. Mitochondrial Electron Transport Chain and Oxidative Phosphorylation. Thermogenesis
    5. 5.5. Oxygen Toxicity
  8. 08Chapter 6. Carbohydrate metabolism
    1. 6.1. Digestion, Absorption and Transport of Dietary Carbohydrates. Disorders of Digestion and Absorption of Carbohydrates
    2. 6.2. Glucose Catabolism. Aerobic Glycolysis, Anaerobic Glycolysis and Complete Oxidation of Glucose
    3. 6.3. Gluconeogenesis. Regulation of Glycolysis and Gluconeogenesis
    4. 6.4. Pentose Phosphate Pathway
    5. 6.5. Synthesis and Degradation of Glycogen
    6. 6.6. Regulation of Glycogen Metabolism
    7. 6.7. Glycogen Storage Diseases
    8. 6.8. The Metabolism of Ethanol in the Liver
  9. 09Chapter 7. Lipid metabolism
    1. 7.1. Structure and Functions of the Major Human Lipids
    2. 7.2. Digestion and Absorption of Dietary Lipids. Transport of Lipids by Chylomicrons
    3. 7.3. Disorders of Lipids Digestion and Transport
    4. 7.4. Synthesis of Fatty Acids and Triacylglycerols - Lipogenesis, Hormonal Regulation. Obesity
    5. 7.5. Mobilization of Stored Fats from Adipose Tissue
    6. 7.6. Utilization of Fatty Acids for Energy Production - в-Oxidation. Disorders of в-Oxidation. The Other Pathways of Fatty Acids Oxidation
    7. 7.7. Synthesis and Oxidation of Ketone Bodies. Ketonemia, Ketoacidosis
    8. 7.8. Structure Metabolism and Biological Effects of Eicosanoids
    9. 7.9. Glycerophospholipids and Sphingolipids, Biological Functions and Metabolism
    10. 7.10. Cholesterol Functions and Metabolism. Regulation of Cholesterol Synthesis
    11. 7.11. Bile Salts, Functions, Synthesis, and Role in the Cholesterol MEtabolism
    12. 7.12. Cholesterol Transport by Blood Lipoproteins
    13. 7.13. Hypercholesterolemia. Biochemical Aspects of Atherosclerosis. Cholesterol-Lowering Agents
  10. 10Chapter 8. Nitrogen metabolism
    1. 8.1. Digestion of Proteins and Amino Acid Absorption. Essential Amino Acids
    2. 8.2 Transamination and Deamination of Amino Acids
    3. 8.3. Ammonia Detoxification. Urea Cycle. Urea Cycle Disorders, Hyperammonemia
    4. 8.4. Synthesis of Nonessential Amino Acids
    5. 8.5. The Main Steps of Amino Acid Degradation; Glucogenic, Ketogenic and both Gluco-and Ketogenic Amino Acids
    6. 8.6. Special Pathways of Some Amino acids: Phenylalanine Metabolism, Tetrahydrofolate, Vitamin B12 and s-Adenosylmethionine
    7. 8.7. Decarboxylation of Some Amino Acids, Synthesis of Neurotransmitters and Hormones
    8. 8.8. Special Products Derived from Amino Acids
  11. 11Chapter 9. Molecular endocrinology
    1. 9.1. Role of Hormones in Regulation of Metabolism and Functions
    2. 9.2. Structure, Synthesis and Basic Action of Hormones of the Hypothalamus and Pituitary Gland
    3. 9.3. Structure, Synthesis and Basic Action of Principal Hormones Regulating Fuel Metabolism
    4. 9.4. Hormonal Regulation of Fuel Metabolism at Normal Nutrition Rhythm
    5. 9.5. Metabolic Changes During Starvation
    6. 9.6. Metabolic Changes During Muscle Activity
    7. 9.7. Metabolic Changes in Hypoand Hypersecretion of Hormones
    8. 9.8. Metabolic Changes in Diabetes Mellitus
    9. 9.9. Actions of Hormones Regulating Sodium and Water Balance
    10. 9.10. Actions of Hormones that Affect Calcium and Phosphate Levels
    11. 9.11. Disorders of Calcium Metabolism
  12. 12Chapter 10. Tissue metabolism. Liver detoxification function
    1. 10.1. Mechanism of Toxic Compounds Detoxification
    2. 10.2. Putrefaction in Large Intestine and Detoxification of Formed Products
    3. 10.3. Biotransformation of Medicines
    4. 10.4. Metabolism and Detoxification of Ethanol
    5. 10.5. Chemical Charcinogenesis

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